It's really impossible to say without knowing the rest of the setup. What heads are you running? Cam? Intake/runners/plenum?
Basically, are you doing anything to the engine that will increase it's airflow by much? If so, then more fuel will be needed to match, which could mean higher flow injectors. If not, then 22 pounders will probably be fine. You can always bump the fuel pressure up a little if a tad more flow is needed, provided that you install an adjustable fuel pressure regulator.
You might look into a set of Bosch design 3's, even if you do wind up staying with 22#. They have a better spray pattern than the stock multecs, and can be had relatively cheap. Here's one example:
http://cgi.ebay.com/ebaymotors/LS1-I...item4143e90a0e
You can tell the design 3's by the really narrow injector body. I run bosch design 2s in my car, but 19#, since it's a 305. They're still better than the stock multecs, but the design 3's are supposed to be better.