I have the regulator in the back on the driver side and the other line going to the front on the passengerside. I have the crossover tube in the rear. Just like this picture: http://community.webshots.com/photo/...37512304PRlKTF

Now is it possible that this could cause any problems like a ruff running engine? Also what are the feed and return lines on the frame rail and which one connects to which?

 

What you describe, should work.

The larger fuel line is the feed line, the smaller is return. Alternatively, put both lines in a big coffee can or something, turn the key on, and see which one the fuel comes out of. That's the feed line.

The pressure line should connect straight to one of the rails; then usually the crossover tube would go from the other end of that rail to the other rail; then the regulator would be at the far end of that rail, and the return line would hook to the regulator. The idea being, that the fuel pump pumps just as hard as it can, into the rails; and the regulator lets enough fuel go back down the return, to "bleed off" the pressure in the rails down to its setting.

Beyond that, it doesn't matter, as long as the pattern described above is followed.

 

The way you have it has the front of the drivers side as a dead end. Could get air trapped in there. Don't know if it would really cause a problem just not what would be considered optimum.
Like SofaKindom said, you want to flow into one end of a rail, down to the crossover tube, then down the second rail to the regulator. the regulator will be the last part of the circuit.
If you must run that supply to the front, I would install a "Tee" and run into the front of the drivers rail also.
That way flow goes down both rails to the regulator at the end and then out to the tank.

 

Hooked them up the way Holley recomends and it didnt make any difference...now I need a new o-ring kit for the rails....

 

I have mine with the crossover in the rear and the feed and return in the front of the eng. I used the factory style fuel fittings and ran everything the same way the tpi was setup. looks real clean! I don't like extra fittings near the dizzy. the best part is it was cheaper than buying all those an fittings and braided line.


only down side was I had to cut off the throttle body coolant nipple (which I never used anyway)