You can run pretty much any size cam you want. The cam, however, has to match the rest of the setup. If you have a stock 350 with stock intake and exhaust, putting a cam in will result in a poor running engine. The whole setup must match. If you want a bigger cam, then you will need better gears, better intake, better heads, better exhaust, upgraded fuel system, etc.

What do you have currently?

 

I also noticed your in CO, so that also adds emmissions restrictions. A cam with overlap does not play nicely with O2s. Lots of overlap will cause the fueling to be real rich at idle, which can cause you to fail emmissions, and potentially damage the cat (or cats).

 

The biggest issue with camming up an EFI vehicle is that if it's more than a mild departure from stock, you will need to plan to have a custom chip burned for it. The more radical the cam gets (especially with overlap), the more talent the person tuning it will need.

Another consideration is simply the range of efficiency associated with TPI compared to a carbed motor. A TPI's setup is one that promotes low and midrange torque at the expense of high rpm power. The cam, like all other components, need to be focused at increasing power within the TPI's breathing range, and not extending the RPM range like most high performance items typically do.