I live in Florida and moving to Colorado, is there any changes need to be made to the computer or will it adjust to the different air/fuel mixture?

 

I recently moved from a sea-level location to a higher altitude area. I found lowering my fuel pressure a bit helped the WOT performance since the air is a bit thinner. Other than that, there is nothing you have to do (if it is fuel injected).

You can consider disconnecting the battery to reset the ECM and have it relearn the higher elevation. I have done this, but because I was doing some electrical work on my car.