I've got a 92 trans am with a 305 TPI, has 170000 miles. while driving down the highway, a rod stated knocking. i have a 1969 or 70 350 block, will my my tpi setup bolt right up to my 350?

Yes.
But you'll have to oval some of the holes in the intake manifold to make it bolt to the heads on your old 350 block.

They will fit fine if you use the heads that are in the car now.

thanks guys, this will help ALOT!!!! now i've just gotta put it in.

Yeah I would definitely switch to a set of 083 heads... But he has the 081s... which may or may not be a good compression range for a 350... but the stock tune isnt gonna work with a 350 anyway.

But yeah, the TPI will bolt up aside from a few intake bolts that are a different angle. I'd consider doing a head swap on that 350 to a set of 083 (TPI Iron L98 heads) heads and trying to find a stock 350 ECM. You'll need a new knock sensor also, and I think there's one other thing you need...

But your TPI system is Speed Density, so you dont have a MAF to help with a tune mismatch. But if you go with stock parts, the tune from a 350 should work.