Iam about to install two ten inch sub in my car i also have 6 cd changer I was thinking about mounting it on the box right between the two subs, how much does a mdf made box vibrate do you guys think Ill have cd skipping issues because of the base.?

 

at higher volumes it'll skip, and even at lower volumes, the non stop vibrations getting transmitted through the circuit boards will likely cause solder joints to losen up to the point where the changer stops working. I'd mount it somewhere else.

 

NEVER mount anything to the box, an amp is even a bad idea.