How many miles do you guys have on your high performance/hp street engines? And what do you have? C.I.? Compression? Aggreesive cam?

I am planning on a 421 build fully forged, compression to run pump gas on street (10-11:1 ?), and I would like a nice aggressive cam (if I can without loosing too much reliability). I am willing to spend money to make this engine very strong, not looking to super charge but looking to get 550-600 hp on motor, no NOS either. How long would you guys expect this motor to last if everything is all new, built strong up and down? Not looking to race at the strip but just to drive around town, run hard at some lights, car shows, maybe even long interstate drives... I want this to be a one time deal. Please reply with experiences with your own engines or others you have seen.

Thanks